Help determine whether a tumor more likely occurred as a result of sporadic or inherited pathogenic variants.
Required Patient Information:
Clinical Diagnosis, Surgical Pathology report
Turn Around Time:
Specimen type: Paraffin embedded tissue
The C region of the MLH1 promoter is amplified by multiplex PCR with two fluorescently-labeled primer pairs: one specific for the methylated allele, and one specific for the unmethylated allele. Individuals with a normal methylation pattern will have amplification of the unmethylated allele only.