Coagulation Panels

Suggested tests are listed below for bleeding disorders:

Screening tests:
Activated Partial Thromboplastin Time (APTT)
Prothrombin Time/International Normalized Ratio (PT/INR)
Thrombin Time (TT)
Mixing studies
  • PT mixing studies
  • Incubated aPTT mixing studies
Hepzyme (To detect heparin contamination when APTT is prolonged)

Circulating anticoagulant antibodies:
APTT
PT
Mixing studies
  • PT mixing studies
  • Incubated aPTT mixing studies
Lupus anticoagulant screening
Lupus confirmation
Anti-cardiolipen Antibodies
Anti-B2 GP1 antibodies

Von Willebrand:
APTT
Factor VIII Activity
vWF Antigen
Ristocetin Cofactor
Platelets aggregation with ristocetin
vWF Multimers
Collagen binding assay
Exon 28 sequencing

Platelet Function:
Platelet count
Platelet Aggregation
Sticky platelet syndrome assay
Bleeding Time
Prothrombin Consumption Test
PFA-100
Clot Retraction
ATP release

Disseminated Intravascular Coagulation:
APTT
PT
Thrombin Time (TT)
Antithrombin activity
Fibrinogen clottable
D-dimer
Peripheral blood smear morphology

Thrombotic hypercoagulable:
PT
APTT
Mixing studies
  • PT mixing studies
  • Incubated aPTT mixing studies
TT
Lupus Anticoagulant Screen
Lupus Anticoagulant confirmation
Antithrombin III Activity
Factor V Leiden
Protein C Activity
Protein C Antigen
Protein S Activity
Protein S Antigen
Activated Protein C Resistance
Fibrinogen Activity
Fibrinogen Antigen
Plasminogen Activator Inhibitor 1
Plasminogen Activity
Tissue Plasminogen Activator Antigen
Prothrombin G20210A mutation
Homocysteine

Fibrinolysis:
PT
APTT
TT
Fibrinogen
Fibrin(ogen) degradation/split product
Plasminogen Activity
D-dimer

Thrombotic thrombocytopenic purpura:
ADAMS13 activity
ADAMS13 inhibitor

Coagulation factors assays
Fibrinogen
Factor 2 activity
Factor 5 activity
Factor 7 activity
Factor 7 antigen
Factor 8 activity
Factor 9 activity
Factor 9 antigen
Factor 10 activity
Factor 10 antigen
Factor 11 activity
Factor 12 activity
Factor 13 activity

Factor inhibitors
Factor 5 Inhibitor
Factor 7 Inhibitor
Factor 8 Inhibitor
Factor 9 Inhibitor
Factor 10 Inhibitor
Factor 11 Inhibitor
Factor 12 Inhibitor